LGD-4033 (Ligandrol) is one of the most potent SARMs per milligram, and unlike many compounds in this space it has been tested in people. This guide covers what LGD-4033 (Ligandrol) is, what the trials showed and how to buy it.
In this guide
What is LGD-4033 (Ligandrol)?
LGD-4033 is a non-steroidal SARM first developed by Ligand Pharmaceuticals and later licensed to Viking Therapeutics as VK5211. It binds the androgen receptor with very high affinity, a Ki of roughly 1 nM, and is selective for muscle and bone over prostate and skin. Its half-life is 24 to 36 hours.
LGD-4033 research in humans
Basaria and colleagues published a phase I study in 2013. 76 healthy young men took LGD-4033 or placebo for 21 days. Lean body mass rose with dose, and the compound was well tolerated, though HDL and total testosterone fell at higher doses and recovered after stopping.
Viking later ran a phase II trial in 108 older patients recovering from hip fracture surgery and reported gains in lean body mass over 12 weeks. The studies are listed on PubMed.
LGD-4033 in animal research
In primates given LGD-4033 for 13 weeks, lean mass rose, and most of it remained after a 4-week washout.
LGD-4033 safety notes
Testosterone suppression and lower HDL are the most consistent findings. Case reports have also described liver injury. LGD-4033 isn’t approved by the FDA.
Where to buy LGD-4033 (Ligandrol)
Sports Technology Labs sells liquid Ligandrol at 10 mg/mL, 300 mg per 30 mL glass bottle, and LGD-4033 powder in a 2 gram pouch. The current batch tested at 99.74% purity.
LGD-4033 is part of the LGD-4033 and MK-677 stack, the RAD-140 and LGD-4033 stack and the LGD-4033 and YK-11 stack.
Storing liquid and powder ligandrol
Liquids from Sports Technology Labs are dissolved in USP-grade PEG-400 and bottled in UV-resistant glass with a glass dropper fixed into the cap. Keep the bottle upright, tightly capped and out of direct sunlight. Room temperature is fine, and there’s no need to refrigerate. If a bottle gets cold in transit and looks cloudy, let it warm to room temperature and swirl it gently.
Powder ships in a resealable foil pouch. Measuring tools aren’t included, so you’ll need an analytical balance that reads to at least 1 mg. Most labs dissolve it in PEG-400, the same carrier we use for our liquids. Reseal the pouch straight after use and store it somewhere cool, dry and dark.
How to read the COA
Each product page lists the purity and the COA date. Purity is the share of the target compound found by HPLC. The date tells you when that batch was tested. Most listings also show the certificate and the chromatogram in the image gallery, and we’ll email the full document if you ask. A single tall peak at the expected retention time is what you want to see. Small extra peaks are impurities, and the purity figure accounts for them.
LGD-4033 (Ligandrol) FAQ
Is LGD-4033 stronger than Ostarine?
Per milligram, yes. It binds the androgen receptor more tightly, which is why it’s sold at a lower concentration.
Is VK5211 the same as LGD-4033?
Yes. VK5211 is Viking Therapeutics’ code name for the same compound.
Does LGD-4033 suppress testosterone?
Yes, in a dose-dependent way, according to the phase I trial.
Buy LGD-4033 from Sports Technology Labs today, with free US shipping on orders over $149.
Everything sold by Sports Technology Labs is for laboratory research only. It isn’t for human or veterinary use, isn’t a dietary supplement and hasn’t been approved by the FDA. Nothing in this article is medical advice.